Plasmodium falciparumantigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria
نویسندگان
چکیده
منابع مشابه
Plasmodium falciparum antigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria
BACKGROUND Plasmodium falciparum erythrocyte membrane protein 1(PfEMP1) is a family of variant surface antigens (VSA) that mediate the adhesion of parasite infected erythrocytes to capillary endothelial cells within host tissues. Opinion is divided over the role of PfEMP1 in the widespread endothelial activation associated with severe malaria. In a previous study we found evidence for different...
متن کاملTranscriptional variation in the malaria parasite Plasmodium falciparum.
Malaria genetic variation has been extensively characterized, but the level of epigenetic plasticity remains largely unexplored. Here we provide a comprehensive characterization of transcriptional variation in the most lethal malaria parasite, Plasmodium falciparum, based on highly accurate transcriptional analysis of isogenic parasite lines grown under homogeneous conditions. This analysis rev...
متن کاملSevere adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass.
The interplay between cellular and molecular determinants that lead to severe malaria in adults is unexplored. Here, we analyzed parasite virulence factors in an infected adult population in India and investigated whether severe malaria isolates impair endothelial protein C receptor (EPCR), a protein involved in coagulation and endothelial barrier permeability. Severe malaria isolates overexpre...
متن کاملPlasmodium falciparum Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A var Genes
Parasite-encoded variant surface antigens (VSAs) like the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P. falciparum malaria. Parasites causing severe malaria in nonimmune patients tend to express a restricted subset of VSA (VSA(SM)) that differs from VSA associated...
متن کاملVirulence in Plasmodium falciparum malaria: mechanisms of PfEMP1-mediated rosetting
Malaria is one of the most important infectious diseases in the world and the Plasmodium falciparum parasite is the causative agent of most of the severe cases. The pathogenesis of the disease is complex but sequestration and hence microvascular obstruction is associated with virulence of the parasite. Rosetting, the adhesion of a parasitized red cell (pRBC) to two or more non-parasitized RBC i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2014
ISSN: 1471-2334
DOI: 10.1186/1471-2334-14-170